Cell surface transferrin receptor (CD71) is a disulfide-bonded homodimeric glycoprotein. The existence of a receptor for transferrin iron uptake had been recognized over half a century back. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Upon antigen binding, the ADC is internalized, the cleavage of CD71 is expressed by immature proliferating cells and at low levels on resting mature lymphocytes. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Furthermore, CD71 expression is present in all proliferating cells and can capture target cells without prior knowledge of AML subtype. TFRC Reactivity: Human, Mouse, Rat, Monkey ELISA, WB Host: Mouse Monoclonal 1A1B2 unconjugated. Current genetic analysis indicates that the structural genes for transferrin receptor and for a melanoma-associated antigen (p97), and perhaps transferrin itself, each map to a common chromosome in humans. CD71 is expressed on cells from the erythroid lineage but lacking from the majority of mature erythrocytes. Transferrin receptor (p90 CD71) antibody: Transferrin receptor protein 1, serum form antibody: Trfr antibody: Target information. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. Current genetic analysis indicates that the structural genes for transferrin receptor and for a melanoma-associated antigen (p97), and perhaps transferrin itself, each map to a common chromosome in humans. Sales & Advice: UK +44 (0) 1223 755950 US +1 832 327 7413 @ £ Pound Sterling. Exosomal proteins of colorectal cancer cells. CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. The transferrin receptor is essential for iron transport into proliferating cells. There is a noted implication in Immunodeficiency 46. Transferrin receptor 2 (TFR2), the gene mutated in hemochromatosis type 3 1 is a transmembrane protein homologous to TFR1. CD71 mediates one of the cellular mechanisms for iron uptake, and its expression is regulated according to the cell's iron requirements. Description transferrin receptor Also known as 2610028K12Rik, CD71, E430033M20Rik, Mtvr1, TFR, TFR1, TR, Trfr, p90 Species Mus musculus Entrez ID 22042. Transferrin receptor 1, also known as CD71, is an integral membrane protein that mediates the uptake of diferric transferrin complexes via receptor-mediated endocytosis (18). In addition to being an abundant tumor antigen, CD71 is highly expressed on normal cells, precluding targeting by a traditional antibody drug conjugate (ADC). Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. CD71 is the transferrin receptor (TfR). Like many other proteins involved with iron metabolism, transferrin receptor is regulated by iron … Boster Bio Anti-Transferrin Receptor (CD71) TFRC Rabbit Monoclonal Antibody catalog # M00591-1. The immature reticulocyte fraction, the proportion of reticulocytes with the highest content of RNA, has been determined by hematology analysis. Other alias names for this protein include: transferrin receptor protein 1, CD71, IMD46, T9, TFR1, TR, and TRFR. Other alias names for this protein include: transferrin receptor protein 1, CD71, IMD46, T9, TFR1, TR, and TRFR. clinically. TFRC, CD71, TFR1, TRFR, TFR, TR, CD71 antigen, p90, T9, Transferrin receptor, Transferrin receptor protein 1 surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. For folks with refractory sprue, CD71 gets over-expressed in those individuals with flattened over-proliferation mucosa. Accordingly, transferrin receptors are found predominately on Transferrin receptor 1 (CD71, TFRC) is a type II transmembrane receptor and carrier protein responsible for the uptake of cellular iron through receptor-mediated endocytosis (1). 3502 Background: CX-2029 is a PROBODY drug conjugate (PDC) of MMAE, a potent microtubule inhibitor, directed against CD71 (transferrin receptor 1). Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell) K06503 TFRC, CD71; transferrin receptor. Immunocytochemistry - Anti-Transferrin Receptor antibody (ab84036) ab84036 staining Transferrin receptor protein 1 in HeLa cells. We show that the transferrin receptor CD71 is responsible for apical to basal retrotranscytosis of gliadin peptides, a process during which p31-49 and 33-mer peptides are protected from degradation. This work is the . CD71 is expressed by immature proliferating cells and at low levels on resting mature lymphocytes. IPR037324 Transferrin receptor protein 1/2, PA domain. Transferrin receptor (TfR; CD71) regulates intercellular iron transport and cell growth and is a type II transmembrane glycoprotein [88,89]. The TfR has three domains: extracellular C-terminal, intracellular N-terminal, and transmembrane domain. Transferrin (Tf) plays an important role in the cellular iron uptake. Arenaviruses and the malaria parasite exploit CD71 for cell invasion and epitopes on CD71 for interaction with transferrin and pathogenic hosts were identified. Positively regulates T and B cell proliferation through iron uptake. Transferrin receptor 1. Transferrin receptor 1, dimer, Human. Transferrin receptor (TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. The high rates of binding at the apical surface of enterocytes in patients with active celiac disease indicate that the transferrin receptor CD71 plays a significant role in celiac disease. CytomX is evaluating CX … Iron is required for multiple cellular processes and is essential for DNA synthesis and, thus, cellular proliferation. CD71 expression is variable … Transferrin receptor, also known as CD71 TfR1, is a 760 amino acid, transmembrane glycoprotein of plasma membrane composed of two disulfide-linked monomers encoded by the gene TFRC. This is reported to be a membrane and secreted protein. CD71 expression in blood cells is low, whereas proliferating cancer cells have a higher expression of the surface protein. CD71 / Transferrin Receptor Protein LS-G5078 is a Recombinant Human CD71 / Transferrin Receptor produced in HEK 293 Cells with 6His, N-terminus tag(s). CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. However, the role of transferrin receptor 1 (CD71)-expressing AMs in IPF is not known. JEM VOL. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. first to. Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min. During this process, iron is released and the TfR … This immune response is initiated by intestinal transport of intact peptide 31-49 (p31-49) and 33-mer gliadin peptides through an unknown mechanism. This antibody reacts with an extracellular epitope of CD71 antigen, a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages, and erythroid precursors. D3DXB0, P02786, Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21. Antigen or mitogen stimulation of T and B cells upregulates the expression of CD71. The transferrin receptor is also present on early erythroid cells but is lost as reticulocytes differentiate into mature erythrocytes. A promising candidate is the serum transferrin receptor (sTfR). The microfluidic detection of myeloblasts in blood via the human transferrin receptor (CD71) can serve as a diagnostic marker for acute myeloid leukemia (AML). CD71 is lowly expressed on normal resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. The transferrin receptor 1 (CD71) plays a pivotal role in iron uptake in all vertebrates and its function is crucial for the regulation of iron homeostasis and for cell viability. CD71, also known as transferrin receptor protein 1 (TfR1) , is a transmembrane glycoprotein composed of two disulfide-linked monomers, each of 90 kDa molecular weight. anti-Transferrin Receptor antibody (Transferrin Receptor (p90, CD71)) (AA 608-727) Primary Antibody. first to. CD71 / Transferrin Receptor Transferrin Receptor. The OX-26 monoclonal antibody reacts with rat CD71 also known as transferrin receptor protein 1 (TfR1). CD71 Monoclonal Antibody detects endogenous levels of CD71 protein. Millipore’s CD71 antibodies demonstrate specificity against CD71, a transmembrane glycoprotein receptor for transferrin and involved in iron uptake. This protein is 760 amino acids long, with a mass of 84.9 kDa, and is a member of the Peptidase M28 family, M28B subfamily. CD71, the transferrin receptor, exists as a homodimer on the cell surface and is essential for cellular growth. Currency. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. The transferrin receptor is responsible for transporting iron, via interaction with transferrin, into cells as demanded by metabolic need. Enter the desired item number and quantity to obtain product availability and pricing. UniProt Code History. It facilitates iron uptake via its binding with transferrin, the major iron-carrying protein in systemic circu-lation (18-20). Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell.Thus, transferrin receptor maintains cellular iron homeostasis. Antigen or mitogen stimulation of T and B cells upregulates the expression of CD71. CD71, the transferrin receptor, exists as a homodimer on the cell surface and is essential for cellular growth. Lenti ORF particles, TFRC (mGFP-tagged) - Human transferrin receptor (p90, CD71) (TFRC), mGFP-tagged, transcript variant 1, 200ul, >10^7 TU/mL 200 ul 200 ul USD 850.00 CD71 binds to two molecules of transferrin and a serum irontransport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. Of particular interest is the prevalence of transferrin receptors (CD71) on cancerous cells, including breast cancer. Protein Names. CD71: a type II transmembrane protein present on activated or proliferating cells that facilitates cellular iron uptake; expressed in many acute leukemias and some lymphomas. Dunsmore G, Koleva P, Ghobakhloo N, et al., 2019, Lower Abundance and Impaired Function of CD71+ Erythroid Cells in Inflammatory Bowel Disease Patients During Pregnancy. Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed: 26642240 ). Alterations in iron metabolism have been described during fibrotic lung disease and in murine models of lung fibrosis. Ligand for transferrin receptor is the serum iron transport protein, transferrin. The Transferrin Receptor (TfR or TfR-1, designated CD71) is a type 2 transmembrane glycoprotein expressed on erythroid progenitors, muscle cells and proliferating cells as a 188 kDa disulfide-linked homodimer of 95 kDa monomers (1-4). 2610028K12Rik, CD71, E430033M20Rik, Mtvr1, Mtvr-1, p90, TfR1, Trfr Feature Type. Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. Transferrin receptor, also known as CD71 or p90, is expressed at the surface of cells that utilize iron. Endosomal acidification leads to iron release. Clone 0X-26 also binds to a number of non-dividing normal tissues. Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. The Human transferrin receptor (CD71) has recently been demonstrated as a cancer cell affinity target in blood samples. Based on the expertise of Upstate & Chemicon. Ascitic fluid containing 0.03% sodium azide. Dendritic cells (DCs) are prominent antigen presenting cells and key regulators of adaptive as well as innate immune responses. IDs. 2,4 In … Transferrin receptor (TfR) is a carrier protein for transferrin.It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Objectives: To assess the role of CD71-expressing AMs in the IPF lung. The CD71 antibody is specific for the human transferrin receptor, with a molecular weight of 190 kilodaltons (kDa), 90-kDa reduced. The reported amino acid length is 760 and the expected mass is 84.9 kDa. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Reference CD71 is a 170-180 kDa type II homodimeric transmembrane glycoprotein which is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. CD71 expression in blood cells is low, whereas proliferating cancer cells have a higher expression of the surface protein. Like many other proteins involved with iron metabolism, transferrin receptor is regulated by iron … Binding of transferrin to its receptor followed by endocytosis of the receptor-ligand complex is a major cellular iron-uptake mechanism. CD71 has been shown to exhibit strong membranous and cytoplasmic staining in all erythroid precursors of normal and dyspoietic bone marrow biopsies (1,2). CD71 expression is variable … - Find MSDS or SDS, a COA, data sheets and more information. clinically. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. CD71 (transferrin receptor), a cell surface proliferation marker, is involved in the cellular uptake of iron (1-3). CD71 has been shown to exhibit strong membranous and cytoplasmic staining in all erythroid precursors of normal and dyspoietic bone marrow biopsies (1,2). CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. s). Transferrin receptor protein 1 (TfR1) also known as CD71 (Cluster of Differentiation 71) is a protein that in Humans is encoded by the TFRC gene. BACKGROUND: CD71 is a homodimeric type II transmembrane glycoprotein consisting of two disulfide-bonded 95 kDa chains. CD71/TRFC/Transferrin Receptor Antibody (H68.4) is a monoclonal anti-CD71 antibody that detects m, r, and h CD71 by WB, IP, IF, IHC(P) and FCM. Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. CD71 is a 200kD glycoprotein composed of two identical, disulfide-linked chains. The use of an The C2 monoclonal antibody specifically binds to CD71, the transferrin receptor. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. Ligand for transferrin receptor is the serum iron transport protein, transferrin. TRANSFERRIN RECEPTOR 1; TFR1 TFR TRFR CD71 HGNC Approved Gene Symbol: TFRC. The Human transferrin receptor (CD71) has recently been demonstrated as a cancer cell affinity target in blood samples. The R17 217.1.3/TIB-219 monoclonal antibody reacts with mouse CD71 also known as transferrin receptor protein 1 (TfR1). Disulfide-bonded homodimeric type II transmembrane molecule (about 760 amino acids) About 671 amino acid extracellular C-terminal domain (binds transferrin) 28 … Tested in IP, WB applications. This protein is 760 amino acids long, with a mass of 84.9 kDa, and is a member of the Peptidase M28 family, M28B subfamily. CD71 (transferrin receptor) is an activation marker and can be expressed on different immune cells including T cells . Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,018,693-196,082,122 (from NCBI) Gene-Phenotype Relationships. CD71 Transferrin Receptor Antibody is a Mouse monoclonal antibody for human cds against CD71 Transferrin Receptor. The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf. DOI 10.1093/ ecco-jcc/jjy147. Molecular Reagents This antibody does not block binding of transferrin to the receptor. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. Post-transcriptional regulation. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis . TfR production in the cell is regulated according to iron levels by iron-responsive element-binding proteins, IRP1 and IRP2. These proteins exhibit primary sequence homology with transferrin … CD71 (90-95 kDa) is a two-disulfide-bonded homodimeric glycoprotein (180 kDa) present on activated T and B cells, a subset of reticulocytes and on many activated proliferating cells. validate CD71 as a new target for antibody drug conjugates (ADC. Authors identified the transferrin receptor-1 (CD71) to be differentially expressed in neural stem cells and differentiated neurons. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. TFRC formira interakcije sa GABARAP i HFE. Breast Cancer Research and Treatment, 119, 283-293 (2010) Arl3 and LC8 regulate dissociation of dynactin from dynein. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Transferrin Receptor (p90, CD71) (TFRC) (AA 101-760) protein (rho-1D4 tag) Protein. CD71 expression decreases with the maturation of erythrocytes. Millipore’s CD71 antibodies demonstrate specificity against CD71, a transmembrane glycoprotein receptor for transferrin and involved in iron uptake. This mAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
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